Glycolysis! (Mr. W's Music Video)



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SUMMARY: Glycolysis is the first step in cellular respiration. This rap lecture teaches all you need to know about glycolysis at the AP Biology or Freshman Biology level.

LYRICS
Glycolysis is a series of reactions,
Enzymatic actions, energy transactions,
Takes glucose, a molecule so sugary,
Breaks it down for NADH and ATP

It’s an anaerobic cytoplasmic pathway that amazes
Organized easily into three phases,
Investment, cleavage, and energy harvest,
Tell me later which one you like best.

Investment: activation energy’s supplied,
Cleavage: our six carbon sugar divides
Harvest: we get our energy yield,
So beautiful, so intricate keep your eyes peeled

CHORUS
Glycolysis!
Come on sugar, come on sugar, for the breakdown. For the breakdown.

Investment’s like striking a match,
That energy you put in makes the fire catch
For glycolysis investments two ATPs,
Which act as activation energy

Enzymes take phosphate from ATPs
Jam ’em on a glucose rearranging it to fructose,
Leaving Fructose 1- 6 bisphosphate on the table,
With two phosphates, it’s highly unstable!

Moving us to the second phase
The cleaving of Fructose bisphosphate
Cause glycolysis means splitting sugar, you can see
cleavage yields two molecules with carbons three

One is glyceraldehyde 3 phosphate G3P
It continues on our pathway broken down for energy
But the second one an enzyme will immediately,
Convert into a second G3P

CHORUS

Phase 3: G3P gets rearranged and oxidized,
By an enzymatic assembly line,
That harvest energy from each G3P
One NADH and 2 ATPs

Double this yield per G3P
To two NADH and 4 ATPs
That’s the gross yield for every glucose in
A generous accounting of glycolysis’s win

But 2ATPs were invested in phase 1
So you net just two you can use to jump or run,
Put two in, get four out, your net gain is two,
Two ATPs that you can use.

If that doesn’t seem like very much, it’s cause it ain’t,
There’s tons of energy left in pyruvate,
The two three carbon molecules we’re left with at the end.
And what happens to pyruvate is gonna depend,

On the metabolic pathway where pyruvate gets sent,
If its anaerobic it’ll be fermented
But in aerobic cells pyruvate’s termination
Will be the Krebs cycle and total oxidation!

CHORUS

Review: glycolysis starts with investment
of two ATPs to the glucose that we started with,
The product is cleaved into two G3Ps
From which the cell harvests NADH and ATPs.

This anaerobic pathway is respiration’s first phase,
It’s billions of year’s old evolved in ancient days
before O2 accumulated in the seas, before
eukaryotic cells like ours arrived on the scene

It’s everywhere, ubiquitous, in every organism,
Bacteria, sequoia tree, no matter your metabolism,
Happens in the cytoplasm doesn’t need no organelles.
You wanna find glycolysis? Look in any cell!

Nguồn: https://behereonline.com

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  • Between now and the AP exam (5/18/20) Live AP Bio review sessions every Tuesday and Thursday at 2pm PST: go to https://sciencemusicvideos.com/mr-w-live/

    sciencemusicvideos July 13, 2020 2:44 am Reply
  • Thank you, this video summarizes the topic, I will sit for my bio-chem exam next week monday

    Jordan Yanda July 13, 2020 2:44 am Reply
  • wish if the toughest tasks were like this….such 'melodious' studies make life a cakewalk😍😘

    Shabdita Kumar July 13, 2020 2:44 am Reply
  • bars for days!!! That was awesome. Such a fun teacher!!

    Shigi July 13, 2020 2:44 am Reply
  • MCAT in a week. LES GO

    Juliet Capulet July 13, 2020 2:44 am Reply
  • top 10 rappers eminem was to affraid to diss

    CRA1NEY1 July 13, 2020 2:44 am Reply
  • He do be dropping bars doe!

    Henry Singleton July 13, 2020 2:44 am Reply
  • This was amazing

    Vanessa Rodriguez July 13, 2020 2:44 am Reply
  • even after having taken AP Bio a year ago already, I still come back to your music videos because they are just great!

    helicas July 13, 2020 2:44 am Reply
  • I first heard this rap 5 years ago in my AP biology class. I am now listening to it while I study for MCAT. My this video has aged well!

    Jillian Skerchak July 13, 2020 2:44 am Reply
  • I just want to thank this man. Not only was that amazingly catchy and hilarious, it was super informative and gave me the refresher on glycolysis that I needed. Thank you thank you thank you Mr. W lol!

    Christy Daugherty July 13, 2020 2:44 am Reply
  • Yesssssss. Please do one for the electron transport chain!

    lawrence mersino July 13, 2020 2:44 am Reply
  • Me gustaria con subtitulos en español

    Lee Chishan Gañan Jaramillo July 13, 2020 2:44 am Reply
  • En español:( i love u

    Juan Torres July 13, 2020 2:44 am Reply
  • I learn nothing and just bob my head with the rhythm! Its really cool:) 👍

    lost gaze July 13, 2020 2:44 am Reply
  • i’m sharing this with a bunch of my friends because you helped me get my degree 🥺😂🤍

    Anna G. De Leon-Oca July 13, 2020 2:44 am Reply
  • The breakdown hits harder than my stepdad

    Guy Incognito July 13, 2020 2:44 am Reply
  • drop the mix tape glenn

    Simran Lazrado July 13, 2020 2:44 am Reply
  • This quarantine got me watching everything in this app

    jay dope July 13, 2020 2:44 am Reply
  • Shit* trying not to laugh
    my parents won't believe that I was actually studying 😂😂😂😂

    Mansi Koerala July 13, 2020 2:44 am Reply
  • Amazing sir Thanks a lot

    jyoti bansile July 13, 2020 2:44 am Reply
  • 🔥🔥🔥🔥🔥

    Bon Holliday July 13, 2020 2:44 am Reply
  • Thank you this will be catchy enough for me to remember the material, and actually enjoy learning.

    Christine Vakas July 13, 2020 2:44 am Reply
  • This guy is my actual teacher at Berkeley High School. Feels good to be taught by a celebrity.

    SoKaar’s Legion July 13, 2020 2:44 am Reply
  • I love the music video Sir! Especially the chorus, it really made a great impression! I simply love it!! <3

    Neil Christian Bolotaolo July 13, 2020 2:44 am Reply
  • My friend says she loves your video

    Katherine Sanchez July 13, 2020 2:44 am Reply
  • Im in love with mr w

    Joseph Schommer July 13, 2020 2:44 am Reply
  • I remember when I first heard this song. Our biology teacher showed us this video and we all learnt it for our biology quiz on glycolysis and cellular respiration. That was back in 2013 when I was in 7th grade. Yet here I am, 7 years later and I still know every lyric to the song and have used it endless times during high school and now that I am studying medicine.

    May my biology teacher rest in peace, and thank you Mr.W for this amazing tutorial which has helped me and my classmates lots.

    Best. Song. Ever. For. Studying. Glycolysis.

    Melissa Garza Martínez July 13, 2020 2:44 am Reply
  • Highly cringe but reaaaaaally helps me in remembering the processes 😂 I am throughly enjoying your vids!

    Anony Nomous July 13, 2020 2:44 am Reply
  • The chorus is generally unreal I sing it all the time

    cengiz July 13, 2020 2:44 am Reply
  • 0:40

    Mikus Kacz July 13, 2020 2:44 am Reply
  • CAN YOU PLEASE BE MY LECTURER?

    Mosa Dondolo July 13, 2020 2:44 am Reply
  • If I came across u earlier I would have topped.But Alas!

    Doctor to be July 13, 2020 2:44 am Reply
  • this is very very fire, actually.

    Olus July 13, 2020 2:44 am Reply
  • Superp

    puja Kumari July 13, 2020 2:44 am Reply
  • Aww man I needed a good refresher for exercise physio, took my a&p classes a few semesters ago, lol this was perfect

    Dragon Bourne July 13, 2020 2:44 am Reply
  • spitting fire

    Jaw Hacks July 13, 2020 2:44 am Reply
  • I had to slow the playback speed to 0.5 so I could understand better/read the diagrams…and the song still sounds really cool! just a tip for anyone else who needs more time to process things 🙂

    A Raven July 13, 2020 2:44 am Reply
  • Hi class

    Shivalrous July 13, 2020 2:44 am Reply
  • bars!!!

    Fabian Garcia July 13, 2020 2:44 am Reply
  • I usually fast forward these videos but had to take this baby down to .25

    Sid Bauer July 13, 2020 2:44 am Reply
  • The line only I understood is Glycolysis come on sugar sugar for.the breakdown

    Sharada Jire July 13, 2020 2:44 am Reply

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